Hangeshashinto, a traditional Japanese medicine, contains seven herbal crude drugs: pinelliae tuber, Scutellariae Radix, Glycyrrhizae Radix, Zizyphi fructus, Ginseng Radix, Zingiberis Processum Rhizoma, and Coptidis Rhizoma. It reduces prostaglandin E2 levels and affects cyclooxygenase activity. Hangeshashinto is used in Japan to treat gastritis, stomatitis, and inflammatory diarrhea and has been studied in patients with cancer as a treatment for chemotherapy-induced oral mucositis.