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The following ONS interim recommendations are for the use of PPE during clinical oncology care and for safe handling and administration of hazardous cancer drugs based on the Table 1 NIOSH list. The options are presented in descending order from highest-level recommended practice based on supplies of available PPE. Although ONS recognizes that these are not ideal, they are interim guidelines to support decision making and staff and patient safety in clinical care during the COVID-19 pandemic.