Genetic Disorder Reference Sheet: CDH1 and Hereditary Diffuse Gastric Cancer
Suzanne Mahon RN, DNSc, AOCN®, AGN-BC
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Description
Pathogenic variants in the CDH1 gene are associated with hereditary diffuse gastric cancer (HDGC), a poorly differentiated adenocarcinoma that infiltrates into the stomach wall. It causes the stomach wall to thicken without forming a distinct mass, which limits effective screening strategies.