Adrenal insufficiency (AI) is a potential immune-related adverse event (irAE) of immunotherapy (e.g., checkpoint inhibitor). If not identified and treated promptly, AI can be life-threatening. Unlike other irAEs, AI may be irreversible, requiring long-term glucocorticoid and mineralocorticoid replacement. Provider and patient education are essential in the management of immune checkpoint inhibitor–induced AI.
AT A GLANCE
Treatment with immunotherapy may lead to irAEs, such as AI.
Glucocorticoid and mineralocorticoid replacement may be required in patients with AI.
To manage AI over time, advanced practice RNs must be aware of its signs and symptoms.
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Adrenal Insufficiency: Immune Checkpoint Inhibitors and Immune-Related Adverse Event Management
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