Adrenal Insufficiency: Immune Checkpoint Inhibitors and Immune-Related Adverse Event Management

Adrenal insufficiency (AI) is a potential immune-related adverse event (irAE) of immunotherapy (e.g., checkpoint inhibitor). If not identified and treated promptly, AI can be life-threatening. Unlike other irAEs, AI may be irreversible, requiring long-term glucocorticoid and mineralocorticoid replacement. Provider and patient education are essential in the management of immune checkpoint inhibitor–induced AI.

AT A GLANCE

• Treatment with immunotherapy may lead to irAEs, such as AI.
• Glucocorticoid and mineralocorticoid replacement may be required in patients with AI.
• To manage AI over time, advanced practice RNs must be aware of its signs and symptoms.