Electrolyte abnormalities are frequently seen in patients receiving treatment for hematologic malignancies and can affect ongoing treatment. Literature supports the use of an electrolyte replacement protocol using standard dosing to maintain electrolyte balance for high-risk patient populations. An advanced practice nurse–led team developed an inpatient nurse-driven electrolyte replacement protocol. Postimplementation, the average time from laboratory result to medication administration decreased from 344 minutes to 112 minutes. The protocol was also associated with fewer reported incidents of cardiac arrhythmias.