Zoledronic Acid

Zoledronic acid inhibits the resorption of mineralized bone and cartilage. It inhibits the increased osteoclastic activity and skeletal calcium that is induced by stimulatory factors released by malignant tumors. Zoledronic acid is indicated for the treatment of hypercalcemia, multiple myeloma, and osteolytic metastases in solid tumors. Clinical trials are ongoing for zoledronic acid use in osteoporosis, secondary to osteoarthritis and Paget’s disease.