Immune effector cell–associated neurotoxicity syndrome (ICANS) is a potentially life-threatening neurotoxicity associated with immune effector cell therapies (e.g., CAR T-cell, tumor-infiltrating lymphocyte (TIL), bispecific T cell engager (BiTE) therapies). Review this huddle card in a group or individually to learn more about immune effector cell–associated neurotoxicity syndrome (ICANS).