Di Franco, R., Calvanese, M., Murino, P., Manzo, R., Guida, C., Di Gennaro, D., . . . Ravo, V. (2012). Skin toxicity from external beam radiation therapy in breast cancer patients: Protective effects of Resveratrol, Lycopene, Vitamin C and anthocianin (Ixor^®). Radiation Oncology (London, England), 7, 12.

To evaluate the effect of dietary supplements in reducing skin toxicity due to radiotherapy in patients with breast cancer

Patients were treated with either dietary supplements or use of topical prophylactic hyaluronic acid and a topical steroid therapy in case of occurrence of radiodermatitis. Patients who were treated with dietary supplements were perscribed resveratrol, lycopene, vitamin C, and anthocyanins at a does of 2 tablets per day. Patients were not randomly assigned.

• The study sample (N = 71) was comprised of female patients.
• Age ranged from 30–80 years.
• Some patients were receiving adjuvant chemotherapy as well

The study took place in an outpatient setting.

Patients were undergoing active antitumor treatment.

 The study used a retrospective observational design.

Patients were assessed using the Radiation Therapy Oncology Group and European Organisation for Research and Treatment of Cancer skin toxicity scale.

In patients evaluated at various radiation therapy doses, odds ratios and relative risk of development of grade 0–1 and 2–3 skin toxicity were calculated.  All ratios were less than 1.0, which cannot be evaluated. No statistically significant differences were reported, and no analysis of significance was provided.

The study does not provide or report sufficient evidence to draw any conclusions.

• The study had a small sample size, with less than 100 participants.
• The study had a risk of bias due to no control group, blinding, or random assignment.
• Measurement and methods were not described.
• Measurement validity and reliability are questionable.

The study does not provide evaluative evidence for use of dietary supplements to prevent radiodermatitis.