Urea-Based Moisturizer for Kinase Inhibitor-Induced Nail Toxicity

Urea-containing lotion and creams are emollients for topical use and have keratolytic properties. Urea hydrates as well as breaks down the intercellular matrix which results in mild debridement and proportion of normal healing of surface lesions. Urea-based moisturizer was evaluated for its effect on nail toxicities in patients receiving kinase inhibitors. As mechanisms of toxicity with various antitumor agents differ, effects may also differ accordingly.