Online Exclusive Article

Symptom Clusters in Patients With Pancreatic Cancer Undergoing Surgical Resection: Part II

Sherry A. Burrell

Theresa P. Yeo

Suzanne C. Smeltzer

Benjamin E. Leiby

Harish Lavu

Eugene P. Kennedy

Charles J. Yeo

pancreatic cancer, symptom clusters, quality of life, survival, surgery
ONF 2018, 45(4), E53-E66. DOI: 10.1188/18.ONF.E53-E66

Objectives: To explore the relationship between 16 symptom clusters (SCs), clinical and demographic influencing factors, and clinical outcomes over time in patients with pancreatic cancer (PC) undergoing surgical resection.

Sample & Setting: 143 patients with stage II PC undergoing surgical resection were recruited to participate in this longitudinal, exploratory study conducted at Thomas Jefferson University Hospital, a National Cancer Institute–designated cancer center.

Methods & Variables: Quality of life was measured preoperatively and at three, six, and nine months postoperatively. Statistical methods included simple linear and Cox proportional hazard regression.

Results: Preoperative pain was significantly associated with the pain–gastrointestinal SC, and preoperative worry was significantly associated with the mood SC. The strongest negative association with emotional well-being across all study time points was found with the preoperative mood SC. The insomnia–digestive problems SC and the nutritional problems SC demonstrated a trend toward poor survival.

Implications for Nursing: Findings provide evidence that preoperative worry and pain are associated with SC severity and that SCs may have a detrimental effect on quality of life and survival in patients with PC undergoing surgical resection.

Members Only
Not a current ONS member or journal subscriber?

Purchase This Article

Receive a PDF to download and print.