Chemotherapy-induced diarrhea is the abnormal increase in stool liquidity and frequency associated with the administration of chemotherapeutic agents. Diarrhea can be a dose-limiting toxicity for certain chemotherapeutic agents, particularly fluoropyrimidines (e.g., 5-flourouracil) and topoisomerase inhibitors (e.g., irinotecan). Late-onset diarrhea with irinotecan occurs in as much as 80% of patients and can occur from two days to two weeks after drug administration.
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