Multiple treatment options, combined with disease heterogeneity, have created nursing challenges in the management of adverse events during antilymphoma therapy. Testing has revealed that less than half of participating nurses correctly graded peripheral neuropathy and neutropenia related to antilymphoma regimens. This supplement to the Clinical Journal of Oncology Nursing shows how oncology nurses can cultivate critical thinking skills, practice thinking critically in relation to team members and patients, leverage information, and manage workflow to allow more opportunity for critical thinking.