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Interventions to Support Adherence to Oral Anticancer Medications: Systematic Review and Meta-Analysis

Haya Waseem

Pamela K. Ginex

Kapeena Sivakumaran

Gina M. DeGennaro

Sarah Lagler-Clark

Kristine B. LeFebvre

Nicole Palmer

Tejanth Pasumarthi

Paula Rieger

Kelli Thoele

Rebecca L. Morgan

oral anticancer medications, adherence, technology, risk assessment

Problem Identification: This systematic review compared the efficacy of interventions to usual care on adherence to oral anticancer regimens.

Literature Search: Embase®, PubMed®, and CINAHL® were searched for eligible comparative studies published between January 2000 and May 2021. Outcomes of interest included adherence, cancer-related morbidity, quality of life, patient satisfaction, and other patient-specific outcomes.

Data Evaluation: Reviewers assessed risk of bias using the Cochrane Risk of Bias 2 tool and Risk of Bias in Nonrandomized Studies of Interventions. Certainty of evidence was assessed using the GRADE framework.

Synthesis: Risk assessment, ongoing or periodic assessment, proactive follow-up, motivational interviewing, or structured programs may improve adherence. Education or coaching interventions may improve or have little to no effect on adherence. Technological interventions may improve adherence, but interactive compared to noninteractive technology may have little to no effect.

Implications for Research: As more cancer treatments move to oral formulations, work remains to identify the most effective interventions to support people receiving oral anticancer regimens.

Supplementary material can be found at

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